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September 1999 Cover
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Recent studies have indicated that protease inhibitors may raise blood lipids to levels that pose an extremely serious health risk. Researchers conducted a study
to determine whether interventions outlined by the National Cholesterol Education Program (NCEP) Guidelines would be effective in reducing protease
inhibitor-related hyperlipidemia. The study involved 45 HIV-infected individuals taking protease inhibitors, with abnormally high lipid levels. Interventions consisted of diet,
exercise, the prescription drug gemfribozil alone or with atorvatstatin. During a 10-month period of intervention, the mean cholesterol level of participants dropped to 201
mg/dl, a substantial decline. Because the study cohort was small, investigators recommend further research. In addition, they note that more aggressive use of lipid
lowering agents was used than that specified by the NCEP.
Editor's Note: from the Journal of the Association of Nurses in AIDS Care
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