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February 2001 Cover
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New studies in the Proceedings of the National Academy of
Sciences discuss the role of a group of proteins, called proteasomes, that HIV uses to assemble and spread new viral particles to uninfected cells. According to
an author of one of the studies, test tube studies indicate that inhibiting the action of these proteins can decrease the spread of HIV by 98 percent. Researchers warned, however, that the tests were only done in test tubes, and
the proteasomes inhibitors will be tested in monkeys before any human studies are conducted. Also noted was that while the proteasome inhibiting strategy shows promise, "it is possible that it may not have any effect
[against HIV] at all." The proteasome function, researchers explained, is critical for healthy cells, so a treatment that inhibits that activity could have an effect on all cells.
Editor's Note: from The Boston Globe
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HIV Digest!
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