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A study of 1255 patients with at least one CD4 count under 100, published in
The New England Journal of Medicine, found that by the second quarter of 1997, the AIDS death rate had decreased to less than
a third of what it had been in 1995; opportunistic infection (OI) rates decreased even more.
During this time the use of prophylaxis against opportunistic infections did not change much, but combination therapy including a protease inhibitor (PI) increased from 2% to 82%. Various statistical
analyses all pointed to the change of treatment, especially combination regimens with protease inhibitors, as the reason for the decreased death and illness.
This study did not analyze the effect of NNRTIs such as nevirapine or delavirdine, which were not widely used when most of these data were being collected.
Editor's Note: from AIDS Treatment News
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